{"id":7184,"date":"2022-08-12T21:41:37","date_gmt":"2022-08-12T21:41:37","guid":{"rendered":"https:\/\/www.ethoderm.com\/?page_id=7184"},"modified":"2022-10-20T22:09:35","modified_gmt":"2022-10-20T22:09:35","slug":"science","status":"publish","type":"page","link":"https:\/\/www.ethoderm.com\/science\/","title":{"rendered":"Science"},"content":{"rendered":"\t\t
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Ethoderm's Science<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Transdermal Carnosine Delivery as Proof of Concept<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Our Core Technology<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Both the currently proven molecule (carnosine) and the core delivery system can disrupt over $80B+ in markets.\u00a0<\/p>

Historically, delivering carnosine directly to muscle tissue has been shown to be nearly impossible.\u00a0<\/span><\/p>

Our patented delivery system can deliver meaningful and significant amounts of carnosine in under an hour.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Scientific Efforts to Date<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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1. In Vitro<\/em> Proof of Concept<\/h4>

In vitro studies performed in 3D skin models show 60% increase in carnosine concentrations through dermal layers.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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2. Demonstrated Efficacy In Vivo<\/em><\/h4>

In vivo studies performed in model organisms (equine) and humans have shown increases of up to 70% in skeletal muscle in <2 hours.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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3. Established Safety Profile<\/h4>

To date, the product tests clean on all major testing platforms. No adverse events have been reported and skin irritation studies show minimal to no irritation across all subjects tested.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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1. In Vitro Proof of Concept<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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This <\/span>in vitro<\/span> study examined the efficacy of our transdermal delivery system for carnosine compared to placebo and carnosine alone in a 3D model of human skin.<\/span><\/p>

The results found that concentration of carnosine were 3.5x to 4x higher in the Ethoderm formulation compared to placebo.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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2. In Vivo Proof of Delivery<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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This <\/span>in vivo<\/span> study examined the efficacy of our transdermal delivery system for carnosine compared to placebo and carnosine alone in a mammalian model (equine).<\/span><\/p>

A randomized, placebo controlled, crossover design was utilized and muscle biopsies were taken at 30 minute intervals.<\/span><\/p>

This study found that the Ethoderm delivery system delivered carnosine into the skeletal muscle of horses within 60 minutes and saw 50% to 75% increases in intramuscular carnosine after a single dose.<\/span><\/p>

Dieter BP, MACIAS CJ, Sharpe TJ, Roberts B, Wille M, Young A, Reisenaur C, Cantrell B, BAyly WM. Transdermal Delivery of Carnosine into Equine Skeletal Muscle. Comparative Exercise Physiology 2021 17(5):429-434(6).<\/span><\/em><\/p>

https:\/\/www.wageningenacademic.com\/doi\/abs\/10.3920\/CEP200077<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ethoderm’s Science Transdermal Carnosine Delivery as Proof of Concept Our Core Technology Both the currently proven molecule (carnosine) and the core delivery system can disrupt over $80B+ in markets.\u00a0 Historically, delivering carnosine directly to muscle tissue has been shown to be nearly impossible.\u00a0 Our patented delivery system can deliver meaningful and significant amounts of carnosine…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/pages\/7184"}],"collection":[{"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/comments?post=7184"}],"version-history":[{"count":38,"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/pages\/7184\/revisions"}],"predecessor-version":[{"id":7440,"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/pages\/7184\/revisions\/7440"}],"wp:attachment":[{"href":"https:\/\/www.ethoderm.com\/wp-json\/wp\/v2\/media?parent=7184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}